O-Desmethyl gefitinib
O-Desmethyl gefitinib is a pharmacologically active metabolite of gefitinib, formed via CYP2D6 metabolism. It acts as an EGFR inhibitor with an IC50 of 36 nM in biochemical assays. This compound is used in research to study drug metabolism, EGFR signaling pathways, and resistance mechanisms in both cellular and animal models of cancer.
Product Specifications
CAS Number
847949-49-9
Product Name Alternative
CYP2D6, HER1, Inhibitor, Gefitinib, human, Epidermal growth factor receptor, EGFR, ErbB-1, O Desmethyl gefitinib, ODesmethyl gefitinib, O-Desmethyl gefitinib, inhibit, plasma
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
97.17% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.62 mM) ; DMSO:27.5 mg/mL (63.53 mM)
Smiles
Oc1cc2ncnc (Nc3ccc (F) c (Cl) c3) c2cc1OCCCN1CCOCC1
Molecular Formula
C21H22ClFN4O3
Molecular Weight
432.88
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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