(R) -I-BET762 carboxylic acid
(R) -I-BET762 carboxylic acid, the R-enantiomer of I-BET762 carboxylic acid (HY-107443) . I-BET762 carboxylic acid is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid is a BRD4 inhibitor with a pIC50 value of 5.1[1].
Product Specifications
CAS Number
[1786401-70-4]
Product Name Alternative
(R) -Molibresib carboxylic acid; (R) -GSK525762A carboxylic acid; (R) -PROTAC BRD4-binding moiety 2
UNSPSC
12352005
Target
Epigenetic Reader Domain; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-i-bet762-carboxylic-acid.html
Purity
99.50
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=NN=C2[C@@H](CC(O)=O)N=C(C3=CC=C(Cl)C=C3)C4=C(C=CC(OC)=C4)N21
Molecular Formula
C20H17ClN4O3
Molecular Weight
396.83
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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