C004019
C004019 is a small molecule PROTAC that selectively recruits tau and the VHL E3 ligase to induce tau ubiquitination and degradation. This candidate is used in research models of Alzheimer's disease and related tauopathies to study targeted protein clearance in cellular and in vivo systems.
Product Specifications
CAS Number
2417159-57-8
Product Name Alternative
C004019, C-004019, C 004019, MicrotubuleAssociated, Microtubule Associated, PROTAC, tau
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
99.37% (May vary between batches)
Solubility
DMSO:255 mg/mL (246.31 mM)
Smiles
N (CC (NCCOCCOCCOCC (N[C@H] (C (=O) N1[C@@H] (C (NCC2=CC=C (C=C2) C3=C (C) N=CS3) =O) C[C@H] (O) C1) C (C) (C) C) =O) =O) (C) C4=NC (=NC (NCCC5=CC=CS5) =N4) N6CCN (C (C) =O) CCC6
Molecular Formula
C49H70N12O9S2
Molecular Weight
1035.29
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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