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IRC-083927 HCl

IRC-083927 HCl is a novel colchicine-site microtubule polymerization inhibitor with potent in vitro anticancer activity in the low nanomolar range, including against taxane- and vinca-resistant cell lines. It demonstrates significant in vivo efficacy by orally inhibiting the growth of human cervical and breast cancer xenografts in mouse models, supporting its investigation for advanced, resistant cancers.

Product Specifications

CAS Number

955082-09-4

Smiles

Cl.NS (=O) (=O) Nc1ccc (Oc2ccc (cc2) -c2cnc (COc3ccccc3) [nH]2) cc1F

Molecular Formula

C22H19FN4O4S

Molecular Weight

454.47

Storage Conditions

-20°C

Notes

For research use only.

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