RO5068760
RO5068760 is a potent, non-ATP-competitive, and highly selective MEK1/2 inhibitor of the substituted hydantoin class. It demonstrates strong in vitro activity (IC50 = 0.025 μM) and shows superior efficacy in vivo against tumors driven by aberrant MAPK signaling, particularly those harboring the B-Raf V600E mutation.
Product Specifications
CAS Number
947182-25-4
Smiles
[C@H] ([C@@H] (C) C1=CC=CC=C1) (C (NC2=C (F) C=C (I) C=C2) =O) N3C (=O) [C@H] (NC3=O) C4=CC=C (OC[C@@H] (CO) O) C=C4
Molecular Formula
C28H27FIN3O6
Molecular Weight
647.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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