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Mal-Phe-C4-VC-PAB-MMAE

Mal-Phe-C4-VC-PAB-MMAE is made by MMAE conjugated to Mal-Phe-C4-VC-PAB linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody agent conjugate.

Product Specifications

CAS Number

[2259318-51-7]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mal-phe-c4-vc-pab-mmae.html

Purity

99.54

Solubility

DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@@]([C@@H](C)CC)([H])N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCC4=CC=C(N5C(C=CC5=O)=O)C=C4)=O)=O)=O)C=C3)=O)=O)=O)=O)OC)=O

Molecular Formula

C72H105N11O15

Molecular Weight

1364.67

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Auristatin

Available Sizes

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