INCB16562
INCB16562 is a selective, orally active JAK1/2 inhibitor that potently blocks IL-6-induced STAT3 phosphorylation in myeloma cells. It overcomes cytokine and stromal protection, sensitizing cells to chemotherapeutics in vitro and demonstrating anti-tumor efficacy in mouse xenograft models, supporting its research use in hematological malignancies.
Product Specifications
CAS Number
933768-63-9
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
ClC1=C (C=2NC3=C (C=4C (NC=5C3=CC=NC5) =NC=CC4) N2) C (Cl) =CC=C1
Molecular Formula
C19H11Cl2N5
Molecular Weight
380.23
Storage Conditions
-20°C
Notes
For research use only.
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