MI-223

MI-223 is a small molecule inhibitor that targets Mcl-1-mediated homologous recombination DNA repair. By disrupting this pathway, it enhances the cytotoxic effects of replication stress-inducing agents like hydroxyurea and olaparib in cancer cells. This mechanism supports its investigation in oncology research, particularly in studies exploring combination therapies for sensitizing tumors in vitro and in vivo.