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ZK-Thiazolidinone

ZK-Thiazolidinone (TAL) is a potent and selective ATP-competitive inhibitor of PLK1 (IC50 = 19 nM) . It disrupts mitotic processes like centrosome maturation and spindle assembly in vitro, leading to prometaphase arrest in vivo, and inhibits proliferation in various human and mouse tumor cell lines.

Product Specifications

CAS Number

891849-87-9

Smiles

C (C (NCC (F) (F) F) =O) (C#N) =C1N (CC) C (=O) C (=CNC2=CC (CCN3CCCC3) =CC=C2) S1

Molecular Formula

C23H26F3N5O2S

Molecular Weight

493.55

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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