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GSK812397

GSK812397 is a potent and selective noncompetitive CXCR4 antagonist that inhibits X4-tropic HIV-1 entry. It demonstrates nanomolar potency in blocking SDF-1-mediated signaling and infection of diverse clinical isolates in vitro, with favorable pharmacokinetics supporting further research into HIV-1 mechanisms and therapeutic development.

Product Specifications

CAS Number

878197-98-9

Field of Research

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Smiles

C (O) C=1N2C (=CC=CC2=NC1CN (C) [C@@H]3C=4C (CCC3) =CC=CN4) N5CCN (C) CC5

Molecular Formula

C24H32N6O

Molecular Weight

420.55

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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