GSK812397
GSK812397 is a potent and selective noncompetitive CXCR4 antagonist that inhibits X4-tropic HIV-1 entry. It demonstrates nanomolar potency in blocking SDF-1-mediated signaling and infection of diverse clinical isolates in vitro, with favorable pharmacokinetics supporting further research into HIV-1 mechanisms and therapeutic development.
Product Specifications
CAS Number
878197-98-9
Field of Research
Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry
Smiles
C (O) C=1N2C (=CC=CC2=NC1CN (C) [C@@H]3C=4C (CCC3) =CC=CN4) N5CCN (C) CC5
Molecular Formula
C24H32N6O
Molecular Weight
420.55
Storage Conditions
-20°C
Notes
For research use only.
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