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AM-9747

AM-9747 (compound 503) is a potent PRMT5 inhibitor with an Ki value of 0.06 nM. AM-9747 shows antiproliferative[1].

Product Specifications

CAS Number

2691869-82-4

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/prmt5-in-25.html

Concentration

10mM

Purity

99.76

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C2N=C(N)C(C)=CC2=C1)N([C@@H](C3=NC=CC=N3)C)CC4=NC=C(C(F)(F)F)C=C4

Molecular Formula

C24H21F3N6O

Molecular Weight

466.46

References & Citations

[1]Jennifer Rebecca Allen, et al. Novel prmt5 inhibitors. WO2021163344A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PRMT5

Available Sizes

Frequently Asked Questions

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