AM-9747
AM-9747 (compound 503) is a potent PRMT5 inhibitor with an Ki value of 0.06 nM. AM-9747 shows antiproliferative[1].
Product Specifications
CAS Number
2691869-82-4
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prmt5-in-25.html
Concentration
10mM
Purity
99.76
Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C2N=C(N)C(C)=CC2=C1)N([C@@H](C3=NC=CC=N3)C)CC4=NC=C(C(F)(F)F)C=C4
Molecular Formula
C24H21F3N6O
Molecular Weight
466.46
References & Citations
[1]Jennifer Rebecca Allen, et al. Novel prmt5 inhibitors. WO2021163344A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5
Available Sizes
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