PF-00337210
PF-00337210 is an orally bioavailable, ATP-competitive inhibitor selectively targeting VEGFR2 tyrosine kinase. Its inhibition of VEGFR2 phosphorylation disrupts tumor angiogenesis, as demonstrated in in vitro endothelial cell assays and in vivo xenograft models, supporting its investigation as an antineoplastic agent.
Product Specifications
CAS Number
854514-88-8
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
C (NC) (=O) C=1C=2C (=CC (OC=3C4=C (C=C (OCCN5CCOCC5) C=C4) N=CC3) =CC2) OC1C
Molecular Formula
C26H27N3O5
Molecular Weight
461.51
Storage Conditions
-20°C
Notes
For research use only.
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