AP23464
AP23464 is a potent ATP-competitive inhibitor of Src and Abl kinases, including imatinib-resistant Bcr-Abl mutants, with low nanomolar cellular and biochemical activity. It induces cell cycle arrest and apoptosis in Bcr-Abl-expressing cells, making it a valuable research tool for studying CML and kinase resistance mechanisms, though it is ineffective against the T315I mutant.
Product Specifications
CAS Number
845895-51-4
Field of Research
Cell Biology, Signal Transduction
Purity
99.79% (May vary between batches)
Smiles
O=P (C1=CC=C (C=C1) NC2=NC (=NC3=C2N=CN3CCC=4C=CC=C (O) C4) C5CCCC5) (C) C
Molecular Formula
C26H30N5O2P
Molecular Weight
475.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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