Tonantzitlolone
Tonantzitlolone is a natural small molecule that activates TRPC1/4/5 channels and PKCα/θ, inducing insulin resistance by suppressing IRS1 and the PI3K/Akt pathway. It also activates HSF1, promoting a glucose-dependent phenotype, making it a useful research tool for studying metabolism, cellular stress, and diabetes-related mechanisms in vitro.
Product Specifications
CAS Number
845811-30-5
Smiles
O[C@@]12[C@H] (OC (/C=C (/CC) \C) =O) [C@H] (C) C[C@@] (O1) (C (=O) [C@@H] (C) /C=C/C (C) (C) [C@]3 (O[C@@] (C) ([C@@H]2O) CC3) [H]) [H]
Molecular Formula
C26H40O7
Molecular Weight
464.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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