Methionine sulfoximine

Methionine sulfoximine (2-Amino-4- (S-methylsulfonimidoyl) butanoic acid) is an irreversible inhibitor of glutamine synthetase with convulsive effects. Methionine sulfoximine is able to affect the metabolism of glutamate and glutamine, which may provide important insights in neurobiological research. Methionine sulfoximine has also been used to study mechanisms related to epilepsy and its inhibitory potential[1].

Product Specifications

CAS Number

[1982-67-8]

Product Name Alternative

2-Amino-4- (S-methylsulfonimidoyl) butanoic acid

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/methionine-sulfoximine.html

Purity

99.60

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

CS(=N)(=O)CCC(C(=O)O)N

Molecular Formula

C5H12N2O3S

Molecular Weight

180.23

Precautions

H315, H319, H335

References & Citations

[1]Catalytic cooperativity and subunit interactions in Escherichia coli glutamine synthetase: binding and kinetics with methionine sulfoximine and related inhibitors