PD-321852
PD-321852 is a selective Chk1 inhibitor that enhances gemcitabine cytotoxicity in pancreatic cancer models, as demonstrated by in vitro studies showing synergistic chemosensitization and loss of Chk1 protein. This compound is a valuable research tool for investigating DNA damage response pathways and combination chemotherapy strategies.
Product Specifications
CAS Number
622856-21-7
Field of Research
Cell Biology
Smiles
C (CCNC) N1C2=C (C3=C (C (=C2) C4=C (Cl) C=CC=C4Cl) C (=O) NC3=O) C=5C1=CC=C (O) C5
Molecular Formula
C24H19Cl2N3O3
Molecular Weight
468.33
Storage Conditions
-20°C
Notes
For research use only.
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