RG7800

RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.

Product Specifications

CAS Number

[1449598-06-4]

Product Name Alternative

RO6885247

UNSPSC

12352005

Hazard Statement

H315, H317, H318, H334, H335, H341, H361, H370, H413

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/RG7800.html

Purity

99.88

Solubility

1 M HCl : 100 mg/mL (ultrasonic) |Ethanol : 2.5 mg/mL (ultrasonic) |H2O : 1.25 mg/mL (ultrasonic; adjust pH to 3 with HCl)

Smiles

O=C1C=C(C2=NN3C(C(CC)=NC(C)=C3)=C2)N=C4N1C=C(C5CCN(C)CC5)C=C4C

Molecular Formula

C24H28N6O

Molecular Weight

416.52

Precautions

H315, H317, H318, H334, H335, H341, H361, H370, H413

References & Citations

[1]Ratni H, et al. Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy. J Med Chem. 2016 Jul 14;59 (13) :6086-100.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Citation 01

BioRxiv. 2020 Feb.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.|Life Sci Alliance. 2019 Mar 25;2 (2) :e201800268.|Nature. 2021 Aug;596 (7871) :291-295.|Patent. US20230340498A1.