RG7800
RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.
Product Specifications
CAS Number
1449598-06-4
Product Name Alternative
RO6885247
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/RG7800.html
Purity
99.88
Solubility
1 M HCl : 100 mg/mL (ultrasonic) |Ethanol : 2.5 mg/mL (ultrasonic) |H2O : 1.25 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Smiles
O=C1C=C(C2=NN3C(C(CC)=NC(C)=C3)=C2)N=C4N1C=C(C5CCN(C)CC5)C=C4C
Molecular Formula
C24H28N6O
Molecular Weight
416.52
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Ratni H, et al. Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy. J Med Chem. 2016 Jul 14;59 (13) :6086-100.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Citation 01
BioRxiv. 2020 Feb.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.|Life Sci Alliance. 2019 Mar 25;2 (2) :e201800268.|Nature. 2021 Aug;596 (7871) :291-295.|Patent. US20230340498A1.
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