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Methotrexate di-n-butyl ester

Methotrexate di-n-butyl ester is a cell-permeable prodrug of methotrexate, functioning as an antimetabolite and immunosuppressant by inhibiting dihydrofolate reductase. This blockade of tetrahydrofolate synthesis impairs DNA replication, making it a tool for studying anticancer and immunosuppressive mechanisms in both cellular and animal models.

Product Specifications

CAS Number

50602-77-2

Field of Research

Pharmacology & Drug Discovery

Smiles

NC=1C2=C (N=CC (CN (C) C3=CC=C (C (N[C@@H] (CCC (OCCCC) =O) C (OCCCC) =O) =O) C=C3) =N2) N=C (N) N1

Molecular Formula

C28H38N8O5

Molecular Weight

566.65

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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