CGP74514A

CGP74514A is a selective CDK1 inhibitor that induces apoptosis in cancer cells like U937 through caspase activation and mitochondrial events, which can be blocked by Bcl-2 family proteins. It also triggers cell cycle alterations, including p21 upregulation and pRb dephosphorylation. This compound is a valuable research tool for studying cell cycle regulation and apoptosis mechanisms in vitro.