2,2,2-Trichloroethanol
2,2,2-Trichloroethanol, the active form of Chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4) [1].
Product Specifications
CAS Number
[115-20-8]
UNSPSC
12352211
Hazard Statement
H302, H318, H336
Target
Endogenous Metabolite; Potassium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-2-2-trichloroethanol.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC(Cl)(Cl)CO
Molecular Formula
C2H3Cl3O
Molecular Weight
149.40
Precautions
H302, H318, H336
References & Citations
[1]Nikhil K Parelkar , et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332 (3) :803-10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
Curated Selection
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