2,2,2-Trichloroethanol

2,2,2-Trichloroethanol, the active form of Chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4) [1].

Product Specifications

CAS Number

[115-20-8]

UNSPSC

12352211

Hazard Statement

H302, H318, H336

Target

Endogenous Metabolite; Potassium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-2-2-trichloroethanol.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC(Cl)(Cl)CO

Molecular Formula

C2H3Cl3O

Molecular Weight

149.40

Precautions

H302, H318, H336

References & Citations

[1]Nikhil K Parelkar , et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332 (3) :803-10.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite

Available Sizes

Curated Selection

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