Methotrexate diethyl ester
Methotrexate diethyl ester is a cell-permeable prodrug of the antimetabolite methotrexate, functioning as a potent inhibitor of dihydrofolate reductase (DHFR) . This action depletes tetrahydrofolate, thereby blocking thymidylate and DNA synthesis. It is widely used in research for studying anticancer mechanisms and immunosuppression in both cellular and animal models.
Product Specifications
CAS Number
43170-88-3
Field of Research
Pharmacology & Drug Discovery
Smiles
NC=1C2=C (N=CC (CN (C) C3=CC=C (C (N[C@@H] (CCC (OCC) =O) C (OCC) =O) =O) C=C3) =N2) N=C (N) N1
Molecular Formula
C24H30N8O5
Molecular Weight
510.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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