JMV 449 acetate

JMV 449 acetate is a potent and selective neurotensin receptor agonist, demonstrating high affinity (IC50 = 0.15 nM) in binding assays and functional activity (EC50 = 1.9 nM) in guinea-pig ileum contraction. It induces potent, long-lasting hypothermic and analgesic effects in murine models, supporting its use in neuropharmacology and pain research.