PROTAC GDI2 Degrader-1

Compound 21 (PROTAC GDI2 Degrader-1) is a potent and selective degrader of GDI2, exhibiting robust in vivo antitumor efficacy in pancreatic cancer xenograft models. This small molecule is a valuable chemical probe for investigating GDI2-dependent oncogenic pathways in vitro and in vivo within oncology and targeted protein degradation research.