HIF-1α-IN-6

HIF-1α-IN-6 (compound 3s) is a potent HIF-1α inhibitor with IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, reducing HIF-1α expression via mRNA downregulation. It is applied in cancer research for in vitro studies of hypoxia pathways and oncology-related mechanisms.