EGFR-IN-90

EGFR-IN-90 (compound 34) is an orally active EGFR inhibitor that potently targets the EGFRL858R/T790M/C797S mutation with an IC50 of 5.1 nM. It inhibits proliferation of H1975-TM cells (IC50 0.05 μM) and suppresses tumor growth in H1975-TM xenograft models, supporting its use in preclinical research for EGFR-mutant cancers.