GW6340
GW6340 is an intestinal-specific LXR agonist. GW6340 promotes macrophage reverse cholesterol transport (mRCT) [1].
Product Specifications
CAS Number
[405910-78-3]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
LXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gw6340.html
Concentration
10mM
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CC1=CC(OCCCN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=CC(C(F)(F)F)=C4Cl)=CC=C1)N
Molecular Formula
C33H32ClF3N2O2
Molecular Weight
581.07
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Yasuda T, et al. Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo. Arterioscler Thromb Vasc Biol. 2010 Apr;30 (4) :781-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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