AZD-4877
AZD-4877 is a highly potent Eg5 kinesin inhibitor (IC50 = 2 nM) that disrupts mitotic spindle formation, leading to a characteristic monopolar spindle phenotype, cell cycle arrest, and apoptosis. It demonstrates antitumor activity in preclinical models and has been shown to inhibit the proliferation of peripheral blood mononuclear cells in vitro.
Product Specifications
CAS Number
758722-49-5
Product Name Alternative
AZD 4877, AZD4877, AZD-4877, Apoptosis, Eg5
Field of Research
Cell Biology, Signal Transduction
Purity
99.19% (May vary between batches)
Solubility
DMSO:55 mg/mL (109.2 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (9.93 mM)
Smiles
C (N (C (=O) C1=CC=C (C) C=C1) CCCN) (C (C) C) C=2N (CC3=CC=CC=C3) C (=O) C4=C (N2) SN=C4C
Molecular Formula
C28H33N5O2S
Molecular Weight
503.66
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
bs-0895R-BF594-01 20 µL
FSH receptor Polyclonal Antibody, AbBy Fluor™ 594 Conjugated
Sign In for Pricing
View Details bs-0895R-BF594-02 100 µL
FSH receptor Polyclonal Antibody, AbBy Fluor™ 594 Conjugated
Sign In for Pricing
View Details ARP38940_P050-HRP 100 µL
BRD3 Antibody - middle region : HRP (ARP38940_P050-HRP)
Sign In for Pricing
View Details 