GSK-3 inhibitor 3
GSK-3 inhibitor 3 is a potent, selective, and brain-penetrant small molecule that inhibits GSK-3α/β with sub-nanomolar IC50 values. It demonstrates in vivo efficacy by reducing tau phosphorylation at S396 (IC50=10 nM) in an Alzheimer's disease mouse model, supporting its use in researching tauopathies and other neurological disorders.
Product Specifications
CAS Number
2227279-84-5
Product Name Alternative
Microtubule Associated, MicrotubuleAssociated, GSK3, GSK-3, GSK-3 inhibitor 3, GSK3inhibitor3, tau
Field of Research
Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.36% (May vary between batches)
Solubility
DMSO:5.63 mg/mL (13.72 mM)
Smiles
N (C (=O) C1=NC (NC2=CC=C (C#N) C=C2) =NC=C1) C=3C (=CC=NC3) C4=CC=C (F) C=C4
Molecular Formula
C23H15FN6O
Molecular Weight
410.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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