Gramicidin S

Gramicidin S is an anttiboitics. Gramicidin S reduces the cell number of planktonic cells within 20-40 min at a concentration of 40-80 μg/mL. Gramicidin S kills the cells of pre-grown biofilms at concentrations of 100-200 μg/mL, such that no re-growth is possible. The translocation of the peptide into the cell interior and its complexation with intracellular nucleotides, including the alarmon ppGpp, can explain its anti-biofilm effect. The successful treatment of persistently infected root canals of two volunteers confirms the high effectiveness of GS. The broad Gramicidin S activity towards resistant, biofilm-forming E. faecalis suggests its applications for approval in root canal medication.

Product Specifications

CAS Number

113-73-5

Purity

0.98

Smiles

NCCC[C@@H]1NC (=O) [C@H] (C (C) C) NC (=O) [C@@H]2CCCN2C (=O) [C@@H] (CC2C=CC=CC=2) NC (=O) [C@H] (CC (C) C) NC (=O) [C@H] (CCCN) NC (=O) [C@H] (C (C) C) NC (=O) [C@@H]2CCCN2C (=O) [C@@H] (CC2C=CC=CC=2) NC (=O) [C@H] (CC (C) C) NC1=O