PI3K/mTOR Inhibitor-12

PI3K/mTOR Inhibitor-12 is a potent, orally bioavailable small molecule with high selectivity, exhibiting IC50 values of 0.06 nM against PI3Kα and 3.12 nM against mTOR. It demonstrates significant antitumor efficacy in preclinical models, supported by in vitro cell proliferation assays and in vivo xenograft studies, while showing a favorable toxicity profile with reduced liver toxicity.