TNG260
TNG260 is a selective CoREST deacetylase (CoreDAC) inhibitor that potently targets HDAC1 over HDAC3. It reverses STK11 loss-mediated anti-PD1 resistance by modulating the tumor immune microenvironment, reducing neutrophil infiltration and promoting immune-mediated tumor cell killing in preclinical studies.
Product Specifications
CAS Number
2935964-98-8
Field of Research
Epigenetics & Chromatin, Molecular Biology
Purity
99.78% (May vary between batches)
Smiles
O=C (C1=CC=C (C=C1) S (C) (=N) =O) NC2=C (N) C=CC (C3=CC=C (C=C3) F) =C2
Molecular Formula
C20H18FN3O2S
Molecular Weight
383.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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