AS1940477

AS1940477 is a potent and selective p38α/β MAPK inhibitor. It effectively suppresses proinflammatory cytokine production in cellular assays (e.g., PBMCs, synovial cells) and demonstrates significant oral anti-inflammatory efficacy in vivo, including in LPS-challenged rat models. This inhibitor is a valuable tool for researching p38 MAPK signaling in inflammation and related diseases.