AS1940477
AS1940477 is a potent and selective p38α/β MAPK inhibitor. It effectively suppresses proinflammatory cytokine production in cellular assays (e.g., PBMCs, synovial cells) and demonstrates significant oral anti-inflammatory efficacy in vivo, including in LPS-challenged rat models. This inhibitor is a valuable tool for researching p38 MAPK signaling in inflammation and related diseases.
Product Specifications
CAS Number
928344-12-1
Smiles
C (O) [C@H]1CN2C (=C (C (=N2) C3=CC=C (F) C=C3) C4=NN (C (=O) C=C4) C5=C (C) C=CC=C5) NC1
Molecular Formula
C24H22FN5O2
Molecular Weight
431.46
Storage Conditions
-20°C
Notes
For research use only.
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