T1001
T1001 is a small molecule antagonist targeting HIF-2α. It functions by binding to the PAS-B domain, displacing residue M252 and disrupting the HIF-2α/ARNT heterodimerization. This inhibitor is a valuable tool for studying hypoxia signaling pathways in cancer and renal physiology through in vitro and in vivo models.
Product Specifications
CAS Number
56943-06-7
Smiles
BrC1=CC=C ([C@H]2CN3C (=N2) SCC3) C=C1
Molecular Formula
C11H11BrN2S
Molecular Weight
283.19
Storage Conditions
-20°C
Notes
For research use only.
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