Neratinib maleate
Neratinib maleate is an irreversible, orally bioavailable inhibitor selectively targeting HER2 (IC50=59 nM) and EGFR (IC50=92 nM) . It is widely used in preclinical cancer research, demonstrating antitumor activity in both in vitro assays and in vivo models for breast, prostate, and other solid tumors.
Product Specifications
CAS Number
915942-22-2
Product Name Alternative
Neratinib Maleate, HKI 272 Maleate, HKI272 Maleate, HKI-272 Maleate, HKI-272 maleate, HER2, EGFR
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.64% (May vary between batches)
Solubility
DMSO:225 mg/mL (334.27 mM)
Smiles
OC (=O) \C=C/C (O) =O.CCOc1cc2ncc (C#N) c (Nc3ccc (OCc4ccccn4) c (Cl) c3) c2cc1NC (=O) \C=C\CN (C) C
Molecular Formula
C34H33ClN6O7
Molecular Weight
673.11
Storage Conditions
-20°C
Notes
For research use only.
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