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MC-VA-PAB-Exatecan

MC-VA-PAB-Exatecan is a cleavable drug-linker conjugate for constructing antibody-drug conjugates (ADCs) . It incorporates the potent topoisomerase I inhibitor Exatecan, enabling targeted delivery and release of the cytotoxic payload. This conjugate is a key research tool for developing novel ADC therapeutics, with applications in both in vitro cytotoxicity assays and in vivo antitumor efficacy studies.

Product Specifications

CAS Number

2680543-57-9

Product Name Alternative

DrugLinker Conjugates for ADC, DrugLinkerConjugatesforADC

Field of Research

Molecular Biology, Pharmacology & Drug Discovery

Solubility

DMF:≥ 80 mg/mL; DMSO:80 mg/mL (84.39 mM)

Smiles

N (C (OCC1=CC=C (NC ([C@@H] (NC ([C@@H] (NC (CCCCCN2C (=O) C=CC2=O) =O) [C@@H] (C) C) =O) C) =O) C=C1) =O) [C@@H]3C4=C5C (C=6N (C5) C (=O) C7=C (C6) [C@] (CC) (O) C (=O) OC7) =NC=8C4=C (CC3) C (C) =C (F) C8

Molecular Formula

C50H54FN7O11

Molecular Weight

948.02

Storage Conditions

-20°C

Notes

For research use only.

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