IU1-47
IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. IU1-47 inhibits IsoT/USP5 with an IC50 of 20 μM. IU1-47 induces tau elimination in cultured neurons[1].
Product Specifications
CAS Number
[670270-31-2]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/iu1-47.html
Concentration
10mM
Purity
99.68
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
CC1=CC(C(CN2CCCCC2)=O)=C(N1C3=CC=C(C=C3)Cl)C
Molecular Formula
C19H23ClN2O
Molecular Weight
330.85
Precautions
H315, H319, H320
References & Citations
[1]Boselli M, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017 Nov 24;292 (47) :19209-19225.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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