IU1-47

IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. IU1-47 inhibits IsoT/USP5 with an IC50 of 20 μM. IU1-47 induces tau elimination in cultured neurons[1].

Product Specifications

CAS Number

[670270-31-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Deubiquitinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/iu1-47.html

Concentration

10mM

Purity

99.68

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

CC1=CC(C(CN2CCCCC2)=O)=C(N1C3=CC=C(C=C3)Cl)C

Molecular Formula

C19H23ClN2O

Molecular Weight

330.85

Precautions

H315, H319, H320

References & Citations

[1]Boselli M, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017 Nov 24;292 (47) :19209-19225.