GSK866

GSK866 ((S) -GSK47866A) is a selective glucocorticoid receptor agonist, with an IC50 of 4.6 nM[1].

Product Specifications

CAS Number

[1991970-93-4]

Product Name Alternative

(S) -GSK47866A

UNSPSC

12352005

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gsk866.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

NC1=C(C(NC[C@](C(F)(F)F)(O)CN(CC)C(C2=C(C=CC=C2Cl)Cl)=O)=O)C=NN1C3=CC=C(C=C3)F

Molecular Formula

C23H21Cl2F4N5O3

Molecular Weight

562.34

References & Citations

[1]Chandra S Chirumamilla, et al. Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads. Front Immunol. 2017 Nov 1:8:1324.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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