PSB-KD477

PSB-KD477 is a potent and selective synthetic agonist for the orphan receptor GPR18, demonstrating superior activity to THC in β-arrestin recruitment assays without activating CB1, CB2, or GPR55. Its distinct indole-based structure makes it a valuable chemical probe for validating GPR18's physiological roles in vitro and for exploring its involvement in immune regulation and cancer biology, as suggested by preliminary research.