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VRT-043198

VRT-043198 is the active metabolite of VX-765 (Belnacasan) and a potent, BBB-permeable inhibitor of ICE/caspase-1 (Ki=0.8 nM) and caspase-4 (Ki=0.6 nM) . It is widely used in research to investigate inflammasome biology and related pathologies in both cellular and animal models.

Product Specifications

CAS Number

244133-31-1

Field of Research

Cell Biology, Metabolism Research, Protein Biochemistry

Smiles

CC (C) (C) [C@H] (NC (=O) c1ccc (N) c (Cl) c1) C (=O) N1CCC[C@H]1C (=O) N[C@@H] (CC (O) =O) C=O

Molecular Formula

C22H29ClN4O6

Molecular Weight

480.94

Storage Conditions

-20°C

Notes

For research use only.

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