SR1903 TFA

SR-1903 is a dual modulator acting as an inverse agonist of RORγ and an agonist of LXR, with additional binding to PPARγ without activation. It suppresses LPS-induced inflammatory pathways, including TREM-1, IL-6, and IL-33, while promoting lipid metabolism genes like ABCG1. This compound has demonstrated efficacy in preclinical models of autoimmune arthritis and metabolic disorders, reducing inflammation, cholesterol, and body weight.