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HS-152

HS-152 is a novel, reversible small molecule inhibitor that directly targets the catalytic HECT domain of Smurf1. It potently inhibits Smurf1 auto-ubiquitination and its E3 ligase activity, blocking ubiquitin transfer to substrates. This inhibitor is a valuable chemical probe for studying Smurf1-related pathways in bone metabolism, cell polarity, and tumorigenesis in both cellular and animal models.

Product Specifications

CAS Number

2284548-09-8

Smiles

C (=O) (C1=CC (NC (NC (=O) C2=CC=C (Cl) C=C2) =O) =CC=C1) N3CCN (C) CC3

Molecular Formula

C20H21ClN4O3

Molecular Weight

400.86

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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