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GDC-2394

GDC-2394 is a potent and selective orally bioavailable NLRP3 inflammasome inhibitor that also directly suppresses IL-1β. It demonstrates species-specific IC50 values of 0.4 μM (human) and 0.1 μM (mouse) for IL-1β and selectively blocks NLRP3-mediated caspase-1 activation without affecting NLRC4. This profile makes it a valuable tool for investigating NLRP3-driven pathologies in both cellular and animal models of inflammatory and autoimmune diseases.

Product Specifications

CAS Number

2238822-07-4

Field of Research

Cell Biology, Immunology & Inflammation, Protein Biochemistry

Smiles

N (C (NS (=O) (=O) C1=C2N (N=C1) C[C@H] (NC) CO2) =O) C3=C4C (=CC5=C3CCC5) CCC4

Molecular Formula

C20H25N5O4S

Molecular Weight

431.51

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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