GSK3527497 HCl
GSK3527497 is a preclinical, orally and intravenously available small molecule that potently and selectively inhibits the TRPV4 ion channel (IC50 = 12 nM) . It is a research tool for investigating TRPV4's role in heart failure and respiratory disease pathophysiology, with studies demonstrating efficacy in relevant in vivo models.
Product Specifications
CAS Number
2215855-51-7
Smiles
Cl.NC[C@]1 (O) CN (C[C@@H]1Oc1ccc (C#N) c (F) c1) S (=O) (=O) c1ccc (Cl) cn1
Molecular Formula
C17H17Cl2FN4O4S
Molecular Weight
463.3054
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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