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USP7-IN-4

USP7-IN-4 (ALM4) is a potent and selective non-competitive USP7 inhibitor with a 6 nM IC50. It stabilizes p53 and induces p21, leading to anti-proliferative effects in cancer cell lines such as RS4;11 leukemia cells (EC50 = 2.0 nM) . This compound is a valuable chemical probe for studying the USP7-MDM2-p53 pathway in oncology research.

Product Specifications

CAS Number

2196243-57-7

Product Name Alternative

AD-04, AMP 423., AMP-423, USP7 inhibitor ALM4, USP7-IN-2, USP7-IN-4

Field of Research

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Purity

98.27% (May vary between batches)

Smiles

CN1C (=C2C (C (=O) N (CC3 (O) CCN (C (C[C@@H] (C) C4=CC=CC=C4) =O) CC3) C=N2) =N1) C5=CC=C (CN) C=C5

Molecular Formula

C29H34N6O3

Molecular Weight

514.62

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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